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Proceedings Paper

Development of laser-induced fluorescence detection to assay DNA damage
Author(s): Minoti Sharma; Harold G. Freund
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Paper Abstract

The demand to measure high dynamic range isotope ratios on small samples with resonance ionization mass spectrometry (RIMS) continues to increase. This paper discusses high ionization efficiency methods which can be applied to continuous wave (cw) RIMS to potentially achieve several tens of percent ionization efficiencies for certain elements. The primary technique under development to achieve this is an external laser cavity which can generate very high circulating laser powers.

Paper Details

Date Published: 1 July 1991
PDF: 12 pages
Proc. SPIE 1435, Optical Methods for Ultrasensitive Detection and Analysis: Techniques and Applications, (1 July 1991); doi: 10.1117/12.44251
Show Author Affiliations
Minoti Sharma, Roswell Park Cancer Institute (United States)
Harold G. Freund, Roswell Park Cancer Institute (United States)


Published in SPIE Proceedings Vol. 1435:
Optical Methods for Ultrasensitive Detection and Analysis: Techniques and Applications
Bryan L. Fearey, Editor(s)

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