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Proceedings Paper

Noninvasive measurement of regional cerebrovascular oxygen saturation in humans using optical spectroscopy
Author(s): Patrick W. McCormick; Mick Stewart; Gary D. Lewis
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Paper Abstract

Noninvasive diffuse IR transmission spectroscopy is used to measure the attenuation of hemoglobin in the human cerebrovasculature. Experimental data demonstrating the intracranial, cerebrovascular source of the IR signal is presented. An algorithm to quantify per-cent hemoglobin oxygen saturation in the brain from these transmission spectra is outlined. The spectroscopic cerebrovascular hemoglobin saturation measured correlates well with the best clinical reference measurement of brain hemoglobin saturation (n equals 68, r equals 0.74, s equals 3.5), and IR spectroscopy is more sensitive to reduced brain oxygen than analogue or processed electroencephalography (EEG) data (p < .05).

Paper Details

Date Published: 1 May 1991
PDF: 9 pages
Proc. SPIE 1431, Time-Resolved Spectroscopy and Imaging of Tissues, (1 May 1991); doi: 10.1117/12.44200
Show Author Affiliations
Patrick W. McCormick, Henry Ford Hospital (United States)
Mick Stewart, Henry Ford Hospital (United States)
Gary D. Lewis, Henry Ford Hospital (United States)


Published in SPIE Proceedings Vol. 1431:
Time-Resolved Spectroscopy and Imaging of Tissues
Britton Chance, Editor(s)

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