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Proceedings Paper

Differential time-resolved detection of absorbance changes in composite structures
Author(s): Ralph J. Nossal; Robert F. Bonner
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Paper Abstract

Several schemes for using time-resolved spectroscopy to determine changes in optical absorbance of a composite media are discussed. Mathematical division of measured transit-time probabilities yields a difference signal whose logarithmic decay is observable over an extended time range. This signal can be used to obtain reliable estimates of the absolute value of a change in the optical absorption of a sample. In homogeneous media, a ratio of absorbances can be determined from the ratio of the mean values of the transit-time distributions. A three optode detection system may improve the accuracy of detected absorption changes when composite media are examined.

Paper Details

Date Published: 1 May 1991
PDF: 8 pages
Proc. SPIE 1431, Time-Resolved Spectroscopy and Imaging of Tissues, (1 May 1991); doi: 10.1117/12.44174
Show Author Affiliations
Ralph J. Nossal, National Institutes of Health (United States)
Robert F. Bonner, National Institutes of Health (United States)

Published in SPIE Proceedings Vol. 1431:
Time-Resolved Spectroscopy and Imaging of Tissues
Britton Chance, Editor(s)

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