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Proceedings Paper

Digital imaging of Giemsa-banded human chromosomes: eigenanalysis and the Fourier phase reconstruction
Author(s): Zeljko Jericevic; Loris McGavran; Louis C. Smith
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Paper Abstract

The new methodology of chromosome analysis based on eigenanalysis and iterative Fourier synthesis has been developed. The approach is inspired by the analysis developed in electron microscopy of particles, and has been modified to address particular problems of chromosome analysis. Preliminary results on data sets containing 40-80 images for each of the human chromosomes indicate that this methodology provides an improvement of chromosome band resolution and potentially can provide cytogeneticist with some new insights. The proposed procedure is a novel approach in chromosome analysis and represents a significant contribution to quantitative cytogenetics. It opens the possibility of identifying defects in chromosome banding pattern automatically.

Paper Details

Date Published: 1 May 1991
PDF: 14 pages
Proc. SPIE 1428, Three-Dimensional Bioimaging Systems and Lasers in the Neurosciences, (1 May 1991); doi: 10.1117/12.44142
Show Author Affiliations
Zeljko Jericevic, Baylor College of Medicine (United States)
Rugjer Boskovic Institute (Croatia)
Loris McGavran, Denver Children's Hospital (United States)
Louis C. Smith, Baylor College of Medicine (United States)

Published in SPIE Proceedings Vol. 1428:
Three-Dimensional Bioimaging Systems and Lasers in the Neurosciences
James E. Boggan; Leonard J. Cerullo M.D.; Louis C. Smith, Editor(s)

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