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Proceedings Paper

Toward an explanation of laser-induced stimulation and damage of cell cultures
Author(s): Harry Friedmann; Rachel Lubart; Israel Laulicht; S. Rochkind
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Paper Abstract

A general mechanism is proposed, capable of accounting for the stimulating action of visible and infrared lasers on cell cultures, at low laser doses, and the damaging action at larger doses. Laser irradiation is assumed to accelerate the formation of a trans-membrane electrochemical proton gradient in mitochondria. This causes more Ca2+ to be released from the mitochondria to the cytoplasm by an 'antiport' process, using the proton-motive force (pmf). At low laser doses, the additional Ca2+ transported into the cytoplasm (among other factors controlled by the pmf) triggers mitosis and enhances cell proliferation. At higher laser doses, too much Ca2+ is released. This causes hyperactivity of Ca2+-ATPase and exhausts the ATP reserves of the cell. The nature of the photoacceptors and possible ways in which the visible and infrared laser energy is converted by the photoacceptors are discussed.

Paper Details

Date Published: 1 June 1991
PDF: 6 pages
Proc. SPIE 1427, Laser-Tissue Interaction II, (1 June 1991); doi: 10.1117/12.44121
Show Author Affiliations
Harry Friedmann, Bar-Ilan Univ. and Ichilov Medical Ctr. (Israel)
Rachel Lubart, Bar-Ilan Univ. and Ichilov Medical Ctr. (Israel)
Israel Laulicht, Bar-Ilan Univ. and Ichilov Medical Ctr. (Israel)
S. Rochkind, Bar-Ilan Univ. and Ichilov Medical Ctr. (Israel)


Published in SPIE Proceedings Vol. 1427:
Laser-Tissue Interaction II
Steven L. Jacques, Editor(s)

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