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Proceedings Paper

Analysis of kinetic rate modeling of thermal damage in laser-irradiated tissue
Author(s): Sohi Rastegar; Tami N. Fink
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Paper Abstract

Theoretical modeling of the thermal and optical processes involved in the interaction of laser light with tissue has progressed both qualitatively and quantitatively as a tool for understanding laser coagulation and ablation. Optimal procedure and dosimetry prescription for laser irradiation of tissue in various applications requires a knowledge of the thermal damage process in tissue and its dynamic behavior. Previous work in the area of thermal damage modeling date back to the work of Henriques (1947) on pig skin. Agah et al. (1987) have evaluated damage coefficients for human vascular tissue. Interesting work on quantitative histology is in progress by Thomsen et al. (1989) in which thermal damage coefficients are correlated to birefringent microscopic observations. A study of the dynamics of thermal damage and ablation indicate the presence and variation of damage in different tissues even before the onset of the ablative process (Rastegar, et al. 1988). In the present study, using a kinetic rate model for thermal damage, the behavior of the damage model has been analyzed to determine sensitivities of tissue parameters, effects of temperature dependence, and possibility of predictions based on isotherm propagation.

Paper Details

Date Published: 1 June 1991
PDF: 7 pages
Proc. SPIE 1427, Laser-Tissue Interaction II, (1 June 1991); doi: 10.1117/12.44114
Show Author Affiliations
Sohi Rastegar, Texas A&M Univ. (United States)
Tami N. Fink, Texas A&M Univ. (United States)

Published in SPIE Proceedings Vol. 1427:
Laser-Tissue Interaction II
Steven L. Jacques, Editor(s)

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