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Proceedings Paper

Preliminary investigations of laser-mediated cartilage reshaping in the in-vivo rabbit model
Author(s): John Chang; Sergio H. Diaz-Valdes; Brian Jet-Fei Wong
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Paper Abstract

Laser cartilage reshaping has become of clinic interest due to its potential applications for facial plastic surgery. Although the temperature dependent phase transformation oflaser mediated cartilage reshaping has been well described, few studies have examined the reshaping process in an in vivo model and correlated shape change with laser dosimetry in a rigorous fashion. We report preliminary findings of Nd:YAG laser mediated cartilage reshaping ofthe New Zealand White rabbit nasal septum. Four New Zealand white rabbits (3.5 -4.0 kg) underwent submucous resection ofthe nasal septum via a novel surgical approach under anesthesia. The septal cartilage was removed and cut into two equal sized slabs (5 x 1 5 mm); one used as a control, while other was reshaped using an Nd:YAG laser (?=1.32µm, 25W/cm2). Both the control and irradiated cartilages were reimplanted into a subcutaneous pocket in the rabbit's back. All four rabbits survived the submucous resection procedure, with no post-operative complications at 3 months post op. Cartilage reshaping was seen to take place at the thermal range 60-70°C. Further study on the long term viability oflaser reshaped cartilage will be performed by serial biopsies ofthe control and irradiated cartilage grafts at 6 and 12 month intervals for histological and viability assays. The preliminary results are promising thus far, and suggest the feasibility of utilizing the rabbit model in studying laser mediated cartilage reshaping.

Paper Details

Date Published: 17 June 2002
PDF: 5 pages
Proc. SPIE 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII, (17 June 2002); doi: 10.1117/12.441096
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Published in SPIE Proceedings Vol. 4609:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII
Lawrence S. Bass; Eugene A. Trowers; Kenneth Eugene Bartels; Udayan K. Shah; David S. Robinson; Lawrence S. Bass; Kenton W. Gregory; Kenneth Eugene Bartels; Lawrence S. Bass; Brian Jet-Fei Wong; Hans-Dieter Reidenbach; Lloyd P. Tate; Nikiforos Kollias; Abraham Katzir; Timothy A. Woodward; Werner T.W. de Riese; George M. Peavy; Werner T.W. de Riese; Kenton W. Gregory; Michael D. Lucroy; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy; Reza S. Malek; George M. Peavy; Hans-Dieter Reidenbach; David S. Robinson; Udayan K. Shah; Lloyd P. Tate; Eugene A. Trowers; Brian Jet-Fei Wong; Timothy A. Woodward, Editor(s)

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