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Proceedings Paper

Indirect spectroscopic detection of singlet oxygen during photodynamic therapy
Author(s): Bruce J. Tromberg; Tatiana B. Dvornikov; Michael W. Berns
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Paper Abstract

Chemiluminescence (CL) and optical upconversion (OU) are used to measure photosensitizer singlet oxygen production indirectly. Both methods produce light that is blue-shifted relative to the normal photosensitizing wavelength. The emission intensity is proportional to the concentration of singlet oxygen generated and is the result of either decomposition (CL) or energy transfer (OU) processes occurring inside a thin polymer film. Techniques for fabrication and characterization of CL and OU polymer films are discussed.

Paper Details

Date Published: 1 June 1991
PDF: 8 pages
Proc. SPIE 1427, Laser-Tissue Interaction II, (1 June 1991); doi: 10.1117/12.44091
Show Author Affiliations
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic/Univ. of California, Irvine (United States)
Tatiana B. Dvornikov, Beckman Laser Institute and Medical Clinic/Univ. of California, Irvine (United States)
Michael W. Berns, Beckman Laser Institute and Medical Clinic/Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 1427:
Laser-Tissue Interaction II
Steven L. Jacques, Editor(s)

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