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Proceedings Paper

Photodynamic therapy of pet animals with spontaneously occurring head and neck carcinomas
Author(s): Elsa R. Beck; Fred W. Hetzel
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Paper Abstract

Eleven pets with squamous cell carcinomas of the head and neck were treated with PDT using 3.0 mg/kg Photofrin II and a light dose of 300 J/cm2 at 632 nm. All tumors had measurable disease that was recurrent following at least one surgical removal. Ten of the eleven patients achieved a complete remission (CR). Of the ten animals with CR, two relapsed at 11 or 13 weeks while the other eight maintained their CR. Six animals remain disease free to the present time, with durations of 65, 56, 56, 56, 50 and 13 weeks. One died of unrelated causes at 12 weeks, and a second animal died of metastatic disease at 8 weeks. In these two cases, extensive histologic evaluation of the treated areas failed to demonstrate any evidence of residual tumor. Toxicity to the tumor bed or surrounding normal tissue was minimal. When the tumor was located adjacent to bone of the mandible or maxilla, the bone was at risk to form sequestra (in 3/5 cases). Based on these preliminary results, PDT may have applications for human patients with carcinoma of the head and neck.

Paper Details

Date Published: 1 June 1991
PDF: 5 pages
Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); doi: 10.1117/12.44071
Show Author Affiliations
Elsa R. Beck, Henry Ford Hospital (United States)
Fred W. Hetzel, Henry Ford Hospital (United States)


Published in SPIE Proceedings Vol. 1426:
Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques
Thomas J. Dougherty, Editor(s)

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