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Proceedings Paper

Pharmacokinetics of Photofrin II distribution in man
Author(s): David Kessel; Unyime O. Nseyo; Veronique Schulz; Elizabeth Sykes
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Paper Abstract

Plasma samples were obtained from 4 patients at intervals after administration of Photofrin II (2 mg/kg). Total porphyrin in plasma and protein/lipoprotein fractions was estimated after hydrolysis, and levels of different Photofrin II components were measured by HPLC. Pharmacokinetic data are provided relating to rates of loss of total porphyrin from plasma and to pool size and half-lives of sensitizers bound to albumin and lipoprotein fractions. Preferential persistence of the most hydrophobic components of Photofrin II was observed.

Paper Details

Date Published: 1 June 1991
PDF: 8 pages
Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); doi: 10.1117/12.44057
Show Author Affiliations
David Kessel, Wayne State Univ. School of Medicine (United States)
Unyime O. Nseyo, Veterans Administration Medical Ctr. (United States)
Veronique Schulz, Wayne State Univ. School of Medicine (United States)
Elizabeth Sykes, William Beaumont Hospital (United States)


Published in SPIE Proceedings Vol. 1426:
Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques
Thomas J. Dougherty, Editor(s)

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