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Proceedings Paper

Early detection of dysplasia in colon and bladder tissue using laser-induced fluorescence
Author(s): Richard P. Rava; Rebecca R. Richards-Kortum; Maryann Fitzmaurice; Robert M. Cothren; Robert Petras; Michael J. Sivak; Howard H. Levine
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Paper Abstract

Laser induced fluorescence has been explored as an early detection scheme for two clinically important examples of neoplasia: colorectal dysplasia and transitional cell carcinoma in the urinary bladder. In both, it is desirable to detect microscopic and biochemical changes of pre-cancer in order to identify patients at risk for developing invasive carcinoma. This paper will compare the fluorescence obtained from these two pre-cancerous conditions, and discuss the connection between the fluorescence and the morphological/molecular changes occurring in the tissue. The similarities and differences in the fluorescence will be compared to determine the general features of pre-cancerous changes that might be utilized for detection of the disease.

Paper Details

Date Published: 1 June 1991
PDF: 11 pages
Proc. SPIE 1426, Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques, (1 June 1991); doi: 10.1117/12.44048
Show Author Affiliations
Richard P. Rava, Massachusetts Institute of Technology (United States)
Rebecca R. Richards-Kortum, Massachusetts Institute of Technology (United States)
Maryann Fitzmaurice, Cleveland Clinic Foundation (United States)
Robert M. Cothren, Cleveland Clinic Foundation (United States)
Robert Petras, Cleveland Clinic Foundation (United States)
Michael J. Sivak, Cleveland Clinic Foundation (United States)
Howard H. Levine, Cleveland Clinic Foundation (United States)


Published in SPIE Proceedings Vol. 1426:
Optical Methods for Tumor Treatment and Early Diagnosis: Mechanisms and Techniques
Thomas J. Dougherty, Editor(s)

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