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Proceedings Paper

Mechanical and acoustic analysis in ultrasonic angioplasty
Author(s): Paul W. Detwiler; James F. Watkins; Eric A. Rose; A. Ratner; Louis P. Vu; J. Y. Severinsky; Uri Rosenschein
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Paper Abstract

The goal of this study was to investigate the relationship between ultrasonic tissue ablation and passive mechanical elasticity. Experience with ultrasonic angioplasty in experimental settings (in-vivo and in-vitro) together with clinical experience in peripheral vascular disease is reported. A model composed exclusively of a hydroxyproline ballistic gelatin matrix showed a negative correlation between material elasticity and the rate of ultrasonic ablation. This model provided a means of studying the effects of collagen content on ablation, exclusive of other biologic components. Ballistic gelatin ablation (mg/sec) was found to increase logarithmically with decreasing protein concentration over the range studied (20.00 to 1.25%). Ablation as a function of gelatin elasticity behaved in a similar manner. Temperature of the material ablated was also demonstrated to affect the rate of ablation. We conclude that the previously reported differences in ablation between thrombi and blood vessel are predictable based on the large difference in their mechanical elasticity, and that this difference provides a wide margin of safety.

Paper Details

Date Published: 1 May 1991
PDF: 7 pages
Proc. SPIE 1425, Diagnostic and Therapeutic Cardiovascular Interventions, (1 May 1991); doi: 10.1117/12.44028
Show Author Affiliations
Paul W. Detwiler, Columbia Univ. College of Physicians and Surgeons and Albert Einstein College of Medicine (United States)
James F. Watkins, Columbia Univ. College of Physicians and Surgeons (United States)
Eric A. Rose, Columbia Univ. College of Physicians and Surgeons (United States)
A. Ratner, Columbia Univ. College of Physicians and Surgeons (United States)
Louis P. Vu, Columbia Univ. College of Physicians and Surgeons (United States)
J. Y. Severinsky, Columbia Univ. College of Physicians and Surgeons (United States)
Uri Rosenschein, Univ. of Michigan School of Medicine (United States)


Published in SPIE Proceedings Vol. 1425:
Diagnostic and Therapeutic Cardiovascular Interventions
George S. Abela, Editor(s)

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