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Proceedings Paper

Salt-bridge-supported bilayer lipid membrane biosensor for determination of anticancer drug cyclophosphamide
Author(s): Yanli Zhang; Tao Wang; Chunxu Zhang; Hanxi Shen; Fuhuan Chao
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Paper Abstract

A novel biosensor for assaying anticancer drug cyclophosphamide was constructed with salt-bridge supported bilayer lipid membrane modified with tetraphenylborate- cyclophosphamide complex. The modification was achieved by the introduction of the complex into the membrane forming solution. The biosensor show a linear response to the drug over the concentration range 8.96 X 10-6 mol L-1. The effects of coexistent substances and pH on assay were evaluated. The results show that the distinguish merits of this kind of biosensor is the excellently biological compatibility and no need of mediator for ions exchange. It also shows good selectivity and sensitivity for cyclophosphamide assay.

Paper Details

Date Published: 14 September 2001
PDF: 4 pages
Proc. SPIE 4414, International Conference on Sensor Technology (ISTC 2001), (14 September 2001); doi: 10.1117/12.440176
Show Author Affiliations
Yanli Zhang, Nankai Univ. and Institute of Hygiene and Environmental Medicine (China)
Tao Wang, Nankai Univ. (China)
Chunxu Zhang, Nankai Univ. (China)
Hanxi Shen, Nankai Univ. (China)
Fuhuan Chao, Institute of Hygiene and Environmental Medicine (China)

Published in SPIE Proceedings Vol. 4414:
International Conference on Sensor Technology (ISTC 2001)
Yikai Zhou; Shunqing Xu, Editor(s)

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