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Proceedings Paper

Optimal fluorescence imaging of atherosclerotic human tissue
Author(s): Carolyn M.C. Davenport; Andrew L. Alexander; Arthur F. Gmitro
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Paper Abstract

Multispectral imaging was investigated as a technique to exploit the spatial and spectral information available in the diagnosis of atherosclerosis. A diagnostic system is proposed that could provide direct viewing of a standard endoscopic or a total-fluorescence image. In addition, multiple spectral-feature images, each associated with a separate, narrow spectral band, could be obtained and processed to produce an optimized contrast image. In this study, a 'white-light' image and a total-fluorescence image were obtained. In addition, a three- dimensional, multispectral data set was generated, and two methods of utilizing this data were explored: (1) a per-pixel ratio of fluorescence intensities, and (2) an optimized superposition of the spectral-feature images. Fluorescence imaging is found to provide a rich data set possessing great potential for improving the detection and characterization of atheromatous disease.

Paper Details

Date Published: 1 May 1991
PDF: 12 pages
Proc. SPIE 1425, Diagnostic and Therapeutic Cardiovascular Interventions, (1 May 1991); doi: 10.1117/12.44013
Show Author Affiliations
Carolyn M.C. Davenport, Optical Sciences Ctr./Univ. of Arizona (United States)
Andrew L. Alexander, Optical Sciences Ctr./Univ. of Arizona (United States)
Arthur F. Gmitro, Optical Sciences Ctr./Univ. of Arizona (United States)


Published in SPIE Proceedings Vol. 1425:
Diagnostic and Therapeutic Cardiovascular Interventions
George S. Abela, Editor(s)

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