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Proceedings Paper

Optical imaging diagnostics of bladder tissue with optical coherence tomography
Author(s): Tuqiang Xie; Zhigang Li; Mark L. Zeidel; Yingtian Pan
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Paper Abstract

Recently technological advances in optical imaging have shown the promise to provide high-resolution imaging of biotissues. Optical coherence tomography (OCT) enables cross-sectional imaging of highly scattering biological tissues at the axial resolution of 10 micrometers or less and at the depths of up to 2-3 mm, highly desirable for screening various kinds of superficial lesions and the invasion of these lesions. In this study, we applied OCT to examine normal and diseased bladder epithelium, and correlated the results with histological findings. OCT images of rat bladder demonstrate the potential of this method to clearly delineating the micro morphological structures of human bladder tissue. Our results show that the micro morphology of rat bladder such as the urothelium, submucosa and muscles is identified by OCT and well correlate with the histological evaluations. OCT detected edema, inflammatory infiltrates, and submucosal blood congestion, as well as abnormal growth of urothelium. By contrast, surface imaging, which resembles cystoscopy, provided far less sensitivity and resolution than OCT. The results suggest the potential of OCT for noninvasive diagnosis of both bladder inflammatory lesions and early urothelial abnormalities, which conventional cystoscopy often misses, by imaging characterization of the increases in urothelial thickening and backscattering.

Paper Details

Date Published: 17 June 2002
PDF: 6 pages
Proc. SPIE 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII, (17 June 2002); doi: 10.1117/12.439558
Show Author Affiliations
Tuqiang Xie
Zhigang Li
Mark L. Zeidel
Yingtian Pan


Published in SPIE Proceedings Vol. 4609:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII
Lawrence S. Bass; Abraham Katzir; Eugene A. Trowers; Timothy A. Woodward; Werner T.W. de Riese; Kenneth Eugene Bartels; Lloyd P. Tate; George M. Peavy; Michael D. Lucroy; Lawrence S. Bass; Nikiforos Kollias; Kenton W. Gregory; Udayan K. Shah; Brian Jet-Fei Wong; David S. Robinson; Hans-Dieter Reidenbach; Kenneth Eugene Bartels; Lawrence S. Bass; Werner T.W. de Riese; Kenton W. Gregory; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy; Reza S. Malek; George M. Peavy; Hans-Dieter Reidenbach; David S. Robinson; Udayan K. Shah; Lloyd P. Tate; Eugene A. Trowers; Brian Jet-Fei Wong; Timothy A. Woodward, Editor(s)

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