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Proceedings Paper

Effect of spatial distribution of irradiated sites on injury selectivity in vascular tissue
Author(s): Wai-Fung Cheong; Paul R. Morrison; Shawn W. Trainor; Amal K. Kurban; Oon Tian Tan
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Paper Abstract

The purpose of this study is to determine whether the extent of injury induced in blood vessels can be increased by : (a) increasing the number of sites per unit irradiation area, and (b) modifying the irradiation sequence, without compromising selectivity and specificity. Irradiation parameters comprising a wavelength of 585 nm, a pulse duration of 360 microsecond(s) , a spotsize of 3-5 mm diameter, and an energy density range of 7.0-7.5 cm-2 is applied in vivo on an albino pig. The results demonstrated that up to one third overlap of irradiated sites is tolerated without causing irreversible alteration in the epidermis and dermis. Injury remains confined predominantly to vascular tissues, and increases in severity as the sites become closer. Besides site density, the degree of injury also depends on the location of the site (center, boundary, or corner) within the irradiated matrix. These observations concur with inferences from surface temperature measurements made on an in vitro model. Another method for increasing injury is to irradiate in small clusters rather than point by point along a line.

Paper Details

Date Published: 1 June 1991
PDF: 8 pages
Proc. SPIE 1422, Lasers in Dermatology and Tissue Welding, (1 June 1991); doi: 10.1117/12.43936
Show Author Affiliations
Wai-Fung Cheong, Boston Univ. School of Medicine (United States)
Paul R. Morrison, Harvard Medical School (United States)
Shawn W. Trainor, Boston Univ. School of Medicine (United States)
Amal K. Kurban, Boston Univ. School of Medicine (United States)
Oon Tian Tan, Boston City Hospital (United States)

Published in SPIE Proceedings Vol. 1422:
Lasers in Dermatology and Tissue Welding
Oon Tian Tan; Rodney A. White; John V. White, Editor(s)

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