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Proceedings Paper

Histopathologic assessment of water-dominated photothermal effects produced with laser irradiation
Author(s): Sharon L. Thomsen; Wai-Fung Cheong; John Anthony Pearce
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Paper Abstract

As the temperature of heated tissues approach 100 degree(s)C the pathological results of laser irradiation become dominated by the effects of phase changes in tissue water. The tissue effects include tissue desication and, as the temperature passes 100 degree(s)C, steam vacuole formation with expansion and rupture of the vacuoles producing tissue defects without loss of dry tissue mass, the so-called 'popcorn effect'. More rapid rates of steam formation result in explosive rupture of the vacuoles with expulsion of tissue fragments producing ablation, a loss of dry tissue mass. Water-dominated photothermal tissue effects are dependent on (1) diffusion of water vapor in tissues at temperatures below 100 degree(s)C, (2) rate of steam formation over 100 degree(s)C, (3) the mechanical properties of the heated tissues over time and (4) the anatomy of the 'native' target tissue.

Paper Details

Date Published: 1 June 1991
PDF: 5 pages
Proc. SPIE 1422, Lasers in Dermatology and Tissue Welding, (1 June 1991); doi: 10.1117/12.43935
Show Author Affiliations
Sharon L. Thomsen, Univ. of Texas M.D. Anderson Cancer Ctr. (United States)
Wai-Fung Cheong, Boston Univ. School of Medicine (United States)
John Anthony Pearce, Univ. of Texas/Austin (United States)

Published in SPIE Proceedings Vol. 1422:
Lasers in Dermatology and Tissue Welding
Oon Tian Tan; Rodney A. White; John V. White, Editor(s)

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