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Proceedings Paper

Detection of general anesthetics using a fluorescence-based sensor: incorporation of a single-fiber approach
Author(s): Susan B. Abrams; Hillary L. MacDonald; Paul Yager
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Paper Abstract

A fiber-optic sensor for general anesthetics based on the phase transition of phospholipid vesicles has been developed and reported previously. The instrumentation and optics have been designed using two fibers and constructed in a portable configuration to allow multi-site testing. Because the phase transition is highly dependent on the surrounding temperature, it is necessary to obtain a temperature reference signal; use of a single-fiber configuration for both sample and reference permits the addition of a temperature transducer in the optrode without increasing its size. Because of the extreme turbidity of the liposomes, current theory does not predict whether a two-fiber or one-fiber approach will provide superior signal strength. The signal efficiency of the original dual-fiber configuration has been compared to that of a second dual-fiber configuration and a single-fiber system incorporating a fiber-optic coupler. Despite the reduced excitation power reaching the optrode, the single-fiber configuration produces a superior signal intensity. The addition of a custom-made Y-shaped fiber coupler enables switching from a dual-fiber design to the single-fiber optrode design without sacrificing portability.

Paper Details

Date Published: 1 July 1991
PDF: 9 pages
Proc. SPIE 1420, Optical Fibers in Medicine VI, (1 July 1991); doi: 10.1117/12.43860
Show Author Affiliations
Susan B. Abrams, Univ. of Washington (United States)
Hillary L. MacDonald, Univ. of Washington (United States)
Paul Yager, Univ. of Washington (United States)

Published in SPIE Proceedings Vol. 1420:
Optical Fibers in Medicine VI
Abraham Katzir, Editor(s)

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