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Proceedings Paper

Parallel confocal systems for biomedical application
Author(s): Rong Yang; Qingsheng He; Minxian Wu; Yingbai Yan; Guofan Jin
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Paper Abstract

A parallel confocal method including an optical diffractive element, a Dammann grating, is presented. Dammann gratings manufactured with microfabrication technologies have the ability to generate several beams with identical intensity. An optical confocal system combining with a Dammann grating will form multi-channel confocal optical structures, so that it can achieve a planar image instantly without scanning. This parallel confocal fluorescence detection system has the merits of discarding scanning part, compact structure, real time imaging and detection and high S/N ratio, therefore it is suitable for detection of dye-labelled DNA array chips and for other biomedical applications. Structural considerations and design of a parallel confocal fluorescence setup and experimental results of detecting a dye-labeled DNA array chip are presented in this paper.

Paper Details

Date Published: 22 August 2001
PDF: 6 pages
Proc. SPIE 4378, Chemical and Biological Sensing II, (22 August 2001); doi: 10.1117/12.438191
Show Author Affiliations
Rong Yang, Tsinghua Univ. (China)
Qingsheng He, Tsinghua Univ. (China)
Minxian Wu, Tsinghua Univ. (China)
Yingbai Yan, Tsinghua Univ. (China)
Guofan Jin, Tsinghua Univ. (China)

Published in SPIE Proceedings Vol. 4378:
Chemical and Biological Sensing II
Patrick J. Gardner, Editor(s)

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