Share Email Print
cover

Proceedings Paper

Comparative study of Al- and Zn-phthalocyanine uptake in rabbit iliac artery by transadvantitial measurements of induced fluorescence
Author(s): Katia Calligaris Rodrigues; Elaine Aparecida Corbani; Raduan Hage; Janaina Duarte; Landulfo Silveira; Maria Angelica G. Cardoso; Antonio G. J. Balbin Villaverde; Renato Amaro Zangaro; Marcos Tadeu Tavares Pacheco
Format Member Price Non-Member Price
PDF $14.40 $18.00

Paper Abstract

Comparative studies were carried out on the Al- phthalocyanine and Zn-phthalocyanine uptake in iliac artery wall of rabbit, through transadventitial fluorescence measurements. Two 3.5 Kg Norfolk make rabbit were used. The iliac artery was dissected, isolated and clamped at two points, 1.5 cm apart. The experiment comprised three steps, collecting fluorescence spectra at several point inside and outside of the clamped region of the artery. The excitation source was a 488 nm Argon Laser. Firstly, it was measured the pre and post clamping transadventitial fluorescence without the photosensitizer. After that, 50 (mu) L of AlPc or ZnPc solutions in Cremiphor EL, 2.5 (mu) M, were injected locally into the artery clamped region of each rabbit and fluorescence spectra were collected at t equals 0 and 15 min. Finally, elapsed 30 min. Temporal evolution of the drug uptake by the artery wall was studied analyzing the intensities of the fluorescence peaks at 682 and 678 nm for AlPc and ZnPc, respectively. It was found that AlPc is more absorbed and remains for a longer time in the iliac artery wall than the ZnPc.

Paper Details

Date Published: 14 August 2001
PDF: 4 pages
Proc. SPIE 4419, 4th Iberoamerican Meeting on Optics and 7th Latin American Meeting on Optics, Lasers, and Their Applications, (14 August 2001); doi: 10.1117/12.437057
Show Author Affiliations
Katia Calligaris Rodrigues, Univ. do Vale do Paraiba (Brazil)
Elaine Aparecida Corbani, Univ. do Vale do Paraiba (Brazil)
Raduan Hage, Univ. do Vale do Paraiba (Brazil)
Janaina Duarte, Univ. do Vale do Paraiba (Brazil)
Landulfo Silveira, Univ. do Vale do Paraiba (Brazil)
Maria Angelica G. Cardoso, Univ. do Vale do Paraiba (Brazil)
Antonio G. J. Balbin Villaverde, Univ. do Vale do Paraiba (Brazil)
Renato Amaro Zangaro, Univ. do Vale do Paraiba (Brazil)
Marcos Tadeu Tavares Pacheco, Univ. do Vale do Paraiba (Brazil)


Published in SPIE Proceedings Vol. 4419:
4th Iberoamerican Meeting on Optics and 7th Latin American Meeting on Optics, Lasers, and Their Applications

© SPIE. Terms of Use
Back to Top