Share Email Print
cover

Proceedings Paper

Effect of fiber optic probe design on fluorescent light propagation in tissue
Author(s): T. Joshua Pfefer; Kevin T. Schomacker; Norman S. Nishioka
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Fiber optic probes used to deliver and collect light for biomedical fluorescence spectroscopy applications have varied widely in design. Critical design parameters include fiber diameter, tissue fiber-tip spacing, and illumination- collection fiber separation distance. While device design has been shown to influence spectral distributions, previous studies have not thoroughly addressed how probe geometry affects the spatial origin of detected fluorescence or how probe design might be customized for specific tissue sites or applications. We have developed a Monte Carlo model of laser-induced fluorescence and investigated the effect of design parameters on light propagation using gastrointestinal tissue optical properties. The distribution of emission locations for detected fluorescence were calculated. Initial results indicated that average fluorescence emission depth and total signal intensity are highly dependent on fiber size and tissue-fiber spacing. The implications of these results for optimization of probes used in the detection of neoplasia are discussed.

Paper Details

Date Published: 9 July 2001
PDF: 7 pages
Proc. SPIE 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical, (9 July 2001); doi: 10.1117/12.434727
Show Author Affiliations
T. Joshua Pfefer, Massachusetts General Hospital/Harvard Medical School (United States)
Kevin T. Schomacker, Massachusetts General Hospital/Harvard Medical School (United States)
Norman S. Nishioka, Massachusetts General Hospital/Harvard Medical School (United States)


Published in SPIE Proceedings Vol. 4257:
Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical
Donald Dean Duncan; Peter C. Johnson; Donald Dean Duncan; Steven L. Jacques; Peter C. Johnson, Editor(s)

© SPIE. Terms of Use
Back to Top