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Proceedings Paper

Cavitation-induced drug delivery in tumors for cancer chemotherapy: animal studies
Author(s): Rinat O. Esenaliev; Irina V. Larina; Yuliana Ivanova; Taras V. Ashitkov; Robert Thomas; B. Mark Evers
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Paper Abstract

Recently we proposed to use laser- and ultrasound-induced cavitation to enhance delivery of anti-cancer agents from blood into tumor cells through tumor capillary wall, interstitium, and cancer cell membrane. Cavitation threshold can be lowered by using microparticles (with certain optical and acoustic properties) which can accumulate in tumors after injection in blood. Lower cavitation threshold allows for local and pronounced cavitation in tumors and, therefore, may provide safe and efficient delivery of anti-cancer drugs in cancer cells without damage to normal tissues by laser or ultrasound radiation. In this paper, we studied enhanced penetration of model macromolecular (rhodamine-dextran) and real anti- cancer (5-FU) drugs and efficacy of cancer therapy with the use of this technique in nude mice bearing human colon tumors KM20. Our studies showed enhanced penetration of the drugs in irradiated tumors and significant improvement of cancer therapy when radiation was applied in combination with polystyrene particle and 5-FU injections. Complete tumor regression of irradiated tumors was obtained when optimum conditions were used. Our results suggest that this technique can potentially be used for efficient and safe cancer chemotherapy.

Paper Details

Date Published: 9 July 2001
PDF: 5 pages
Proc. SPIE 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical, (9 July 2001); doi: 10.1117/12.434726
Show Author Affiliations
Rinat O. Esenaliev, Univ. of Texas Medical Branch at Galveston (United States)
Irina V. Larina, Univ. of Texas Medical Branch at Galveston (United States)
Yuliana Ivanova, Univ. of Texas Medical Branch at Galveston (United States)
Taras V. Ashitkov, Univ. of Texas Medical Branch at Galveston (United States)
Robert Thomas, Univ. of Texas Medical Branch at Galveston (United States)
B. Mark Evers, Univ. of Texas Medical Branch at Galveston (United States)


Published in SPIE Proceedings Vol. 4257:
Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical
Donald Dean Duncan; Peter C. Johnson; Donald Dean Duncan; Steven L. Jacques; Peter C. Johnson, Editor(s)

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