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Proceedings Paper

Dynamic changes in the elastic modulus of lagomorph nasal septal cartilage during Nd:YAG (lambda = 1.32 um) laser irradiation
Author(s): Kenneth K. H. Chao; Matt A. Burden; Brian Jet-Fei Wong
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Paper Abstract

The elastic modulus of rabbit nasal septal cartilage was measured during Nd:YAG laser (λ= 1.32 μm, 10 seconds, 21.22 W/cm2) radiation. Cyclical force versus displacement curves were generated in cantilevered specimens (9.5 mm x 3.0 mm x 1.0 mm) using a calibrated thin beam load cell and a single axis motorized micropositioner (velocity = 0.3 mm/sec). The laser and a thermopile were positioned above the secured specimen. Samples were irradiated three times with 30 second cooling intervals between each sequential laser exposure. Surface temperature reached a maximum of 65°C. Measurements were recorded before, during, and after each laser irradiation, and then following complete rehydration in normal saline (NS) for 1 hour at 25°C. Following each laser exposure, the sample was sprayed with normal saline delivered via an atomizer to prevent desiccation. Elastic modulus was calculated using a model assuming linear elastic behavior. The modulus in native tissue was 6.08 ± 0.17 Mpa, and this decreased during and after each successive laser exposure (5.41 ± 0.39 Mpa, 4.94 ± 0.46), (5.05 ± 0.104 Mpa, 4.17 ± 0.46 Mpa), (4.23 ± 0.53, 3.71 ± 0.60 Mpa), for the first, second, and third laser exposures, respectively. Following rehydration for one hour in normal saline, the modulus returned to near-baseline values (5.33 ± 0.40 Mpa). The results suggest that molecular changes that occur in the cartilage tissue matrix during laser cartilage reshaping are not accompanied by irreversible changes in the matrix modules.

Paper Details

Date Published: 9 July 2001
PDF: 8 pages
Proc. SPIE 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical, (9 July 2001); doi: 10.1117/12.434708
Show Author Affiliations
Kenneth K. H. Chao, Univ. of Texas Health Science Ctr. at San Antonio and Univ. of Irvine (United States)
Matt A. Burden, Harvey Mudd College (United States)
Brian Jet-Fei Wong, Univ. of California/Irvine (United States)


Published in SPIE Proceedings Vol. 4257:
Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical
Donald Dean Duncan; Peter C. Johnson; Donald Dean Duncan; Steven L. Jacques; Peter C. Johnson, Editor(s)

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