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Study of the characteristics of protease-activated NIR fluorescent probes in tumors by using a 3D high-resolution image system
Author(s): Yueqing Gu; Britton Chance; Ching Hsuan Tung; Ralph Weissleder
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Paper Abstract

The objective of this paper is to study the distribution of the near infrared contrast agents delivered to mice bearing with small tumors in subsurface. Two kinds of contrast agents, NN382:ex760nm/em800nm and CY5.5:ex660nm/em700nm, which were activated by specific enzymes in tumors after bounded with certain delivery vehicle, were studied by using the 3D high spatial resolution image system. Flavoprotein and Nicotinamide adenine dinucleotide in tissue are measured simultaneously as intrinsic agents for study the effect of extrinsic contrast agents on redox state in tumor.

Paper Details

Date Published: 29 June 2001
PDF: 8 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434538
Show Author Affiliations
Yueqing Gu, Univ. of Pennsylvania (United States)
Britton Chance, Univ. of Pennsylvania (United States)
Ching Hsuan Tung, Massachusetts General Hospital/Harvard Medical School (United States)
Ralph Weissleder, Massachusetts General Hospital/Harvard Medical School (United States)

Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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