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Proceedings Paper

Development of a time-domain tomographic system for optical imaging
Author(s): Maria Lepore; Gaetano Urso; Rosario Esposito; Laura Bottalico; M. Esposito; Maria Daniela Falco; Ines Delfino; Pietro Luigi Indovina
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Paper Abstract

A multichannel time-resolved system for medical optical tomography has been developed. Its main components are an eight channel single-photon counting detector and an ultrafast picosecond solid state laser. Several instrumental aspects concerning the optical coupling between the MCP-PMT and the optical fiber bundles, the electronic components and the roto-translation stages control have been examined. Moreover the accuracy limits in the determination of optical properties of phantom objects have been largely investigated taking into account the role played by the theoretical description of light propagation, the instrumental response function (by means of a convolution procedure) and the fitting algorithm. Information on image quality parameters (spatial resolution, contrast and SNR) have been also obtained by measuring Edge Response Function in different experimental conditions. In such a work, aqueous Intralipid solutions have been used as phantom objects. Furthermore, experimental investigations on well controlled inhomogeneous with different optical properties embedded in Intralipid solutions have been carried on. As last step of the work, preliminary imaging of cylindrical objects has been performed and a Linux version of TOAST code has been used in the imaging reconstruction.

Paper Details

Date Published: 29 June 2001
PDF: 11 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434532
Show Author Affiliations
Maria Lepore, INFM and Univ. degli Studi di Napoli Federico II (Italy)
Gaetano Urso, INFM and Univ. degli Studi di Napoli Federico II (Italy)
Rosario Esposito, INFM and Univ. degli Studi di Napoli Federico II (Italy)
Laura Bottalico, INFM and Univ. degli Studi di Napoli Federico II (Italy)
M. Esposito, INFM and Univ. degli Studi di Napoli Federico II (Italy)
Maria Daniela Falco, INFM and Univ. degli Studi di Napoli Federico II (Italy)
Ines Delfino, INFM and Univ. degli Studi di Napoli Federico II (Italy)
Pietro Luigi Indovina, INFM and Univ. degli Studi di Napoli Federico II (Italy)


Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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