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Proceedings Paper

Interplay of tumor vascular oxygenation and pO2 in tumors using NIRS and needle electrode
Author(s): Jae Gwan Kim; Yulin Song; Dawen Zhao; Anca Constantinescu; Ralph P. Mason; Hanli Liu
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Paper Abstract

The effective measurement of dynamic changes of blood and tissue oxygenation of tumors could be valuable for optimizing tumor treatment plans. For this study, a near- infrared spectroscopy system and pO2 needle electrode were used to measure simultaneously changes in total hemoglobin concentration ([Hb]total), oxygenated hemoglobin concentration ([HbO2[) and local oxygen tension (pO2) in the vascular bed of prostate tumors implanted in rats in response to respiratory challenge. The inhaled gas was alternated between air and carbogen (95% oxygen, 5% CO2). Significant changes in tumor vascular oxygenation were observed with an apparent threshold for variation in [HbO2]/[HbO2]max. For comparison, a phantom study was undertaken with 1% intralipid solution and blood. The slope of [HbO2]/[HbO2[max vs. pO2 in the phantom was ten times larger than in the tumor indicating that tumor cells are relatively resistant to oxygenation. This study demonstrates that the NIR technology can provide an efficient, real-time, non-invasive approach to monitoring tumor physiology and is compatible with additional techniques.

Paper Details

Date Published: 29 June 2001
PDF: 8 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434524
Show Author Affiliations
Jae Gwan Kim, Univ. of Texas at Arlington and Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Yulin Song, Univ. of Texas at Arlington and Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Dawen Zhao, Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Anca Constantinescu, Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Ralph P. Mason, Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)
Hanli Liu, Univ. of Texas at Arlington and Univ. of Texas Southwestern Medical Ctr. at Dallas (United States)


Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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