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Proceedings Paper

Optical tomography with early arriving photons: sensitivity and resolution analysis
Author(s): Nanguang Chen; Quing Zhu
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Paper Abstract

Biological tissues are classified as turbid media to visible and near infrared lights. Photons propagating in tissue generally experience hundreds of scattering events before eventually being absorbed or escaping through boundaries. A lot of attention has been paid to exploiting diffusive photon density waves, which is, however, associated with difficulties in image reconstruction. Early arriving photons consist of a very small portion of photons reaching a detector. As they undergo forward scattering, their trajectories aggregate together to form a thin beam which probes limited volume. This makes it possible to implement single scanning scheme and to acquire more independent information for high quality images. This work is a preliminary theoretical study concerning the sensitivity and image resolution of a time-gating system. The Controlled Monte Carlo method was used for simulating migration of early arriving photons. Optical parameters and phantom dimensions were so chosen that they were applicable to breast cancer detection. Acquired edge-spread functions manifest the possibility of millimeter spatial resolution. Sensitivity analysis was derived from perturbations caused by targets of various contrasts and sizes, with respect to different temporal windows.

Paper Details

Date Published: 29 June 2001
PDF: 8 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434507
Show Author Affiliations
Nanguang Chen, Univ. of Connecticut (United States)
Quing Zhu, Univ. of Connecticut (United States)


Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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