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Proceedings Paper

Noninvasive cerebral blood flow monitoring by a dye bolus method:separation of extra- and intracerebral absorption changes by frequency-domain spectroscopy
Author(s): Matthias Kohl-Bareis; Hellmuth Obrig; Jens Steinbrink; Jasmin Malak; Kamil Uludag; Arno Villringer
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Paper Abstract

Tracking a bolus of contrast agent traveling through the cerebral vasculature provides a measure of the blood supply and the blood flow velocity in the respective cerebral tissue. This principle has been the basis for the first approaches in functional MR imaging and is of great value when investigating stroke and other vascularly compromised patients. While the bolus measurement is a standard procedure in clinical MR imaging, optical bolus tracking has not yet become a reliable protocol. Here optical absorption changes induced by bolus signals of the dye indocyanine- green are studied by near infrared spectroscopy on volunteers. The aim is to assess the latency and shape of the absorption change.

Paper Details

Date Published: 29 June 2001
PDF: 5 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434501
Show Author Affiliations
Matthias Kohl-Bareis, Charite Hospital/Humboldt Univ. zu Berlin (Germany)
Hellmuth Obrig, Charite Hospital/Humboldt Univ. zu Berlin (Germany)
Jens Steinbrink, Charite Hospital/Humboldt Univ. zu Berlin (Germany)
Jasmin Malak, Charite Hospital/Humboldt Univ. zu Berlin (Germany)
Kamil Uludag, Charite Hospital/Humboldt Univ. zu Berlin (Germany)
Arno Villringer, Charite Hospital/Humboldt Univ. zu Berlin (Germany)


Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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