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Proceedings Paper

Three-dimensional optical tomographic localization of changes in absorption coefficients in the human brain
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Paper Abstract

We report on the first three dimensional tomographic localization of vascular reactivity in the brain. Using a model-based iterative image reconstruction algorithm we show volumetric spatial changes in the absorption coefficient caused by changes in blood volume. Unlike currently available topographic reconstruction techniques, volumetric reconstruction schemes promise to be capable of spatially distinguishing between signals originating in the cerebral cortex from those originating in the overlying vascular tissues.

Paper Details

Date Published: 29 June 2001
PDF: 11 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434496
Show Author Affiliations
Avraham Bluestone, SUNY/Downstate Medical Ctr. (United States)
Gassan S. Abdoulaev, SUNY/Downstate Medical Ctr. (United States)
Randall Locke Barbour, SUNY/Downstate Medical Ctr. and Polytechnic Univ. (United States)
Christoph H. Schmitz, SUNY/Downstate Medical Ctr. (United States)
Andreas H. Hielscher, SUNY/Downstate Medical Ctr. and Polytechnic Univ. (United States)

Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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