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Proceedings Paper

Preliminary study of near-infrared tomographic imaging of heterogeneous media: simulations and images of excised breast tissue
Author(s): Troy O. McBride; Brian W. Pogue; Wendy A. Wells; Shudong Jiang; Ulf L. Oesterberg; Keith D. Paulsen
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Paper Abstract

A preliminary study of the effect of a spatially heterogeneous background upon near-infrared tomographic imaging is presented using computer simulations and phantom experiments. In simulations, increasing heterogeneity is added to a sample region and the reconstructed images are analyzed. A finite-element reconstruction algorithm based on the frequency-domain diffusion equation is used. A phantom study for a heterogeneous object was performed by embedding an object in excised breast tissue. The ability to distinguish and quantify a heterogeneous inclusion in a heterogeneous background is discussed. In this case, a 20 mm diameter object in a 100 mm background is characterized with up to 75% added heterogeneity in simulation. A 30 mm cube of pork embedded in a 86 mm sample of excised breast tissue is localized and recovered to within 25% of its expected contrast.

Paper Details

Date Published: 29 June 2001
PDF: 7 pages
Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); doi: 10.1117/12.434491
Show Author Affiliations
Troy O. McBride, Dartmouth College (United States)
Brian W. Pogue, Dartmouth College (United States)
Wendy A. Wells, Dartmouth-Hitchcock Medical Ctr. (United States)
Shudong Jiang, Dartmouth College (United States)
Ulf L. Oesterberg, Dartmouth College (United States)
Keith D. Paulsen, Dartmouth College (United States)

Published in SPIE Proceedings Vol. 4250:
Optical Tomography and Spectroscopy of Tissue IV
Britton Chance; Robert R. Alfano; Bruce J. Tromberg; Mamoru Tamura; Eva Marie Sevick-Muraca, Editor(s)

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