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Proceedings Paper

Usefulness of indocyanine green as an infrared marker
Author(s): Yuko Fukami; Manabu Heya; Kunio Awazu
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Paper Abstract

Indocyanide green (ICG) is widely used as a tracer for the non-invasive estimation of liver function. ICG has properties of binding with plasma protein, and has a large absorption peak at 805 nm. There were no reports, however, about the IR absorption peak of ICG at 7.1 micrometers , which absorption coefficient amounts to approximately 13000cm-1. In this study, ICG was exposed to free electron lasers (FELs) with wavelength of 7.1 micrometers and usefulness of ICG as an IR-marker was discussed. ICG film sample was formed on IR-transparent BaF2 crystal substrate and exposed to FELs with the wavelength of 7.1micrometers . After exposure the sample was analyzed by FT-IR and film thickness measurements. As results, ICG ablated with the FEL of the power density of more than 5 W/cm2(equalsPdth), and that the molecular structure of ICG was still stable for the power density of less than Pdth, 3 W/cm2. Therefore, ICG can be considered as a novel infrared marker (IR marker) to the living tissue which absorbs FEL photon energy without changing the IR absorption peak.

Paper Details

Date Published: 2 July 2001
PDF: 6 pages
Proc. SPIE 4259, Biomarkers and Biological Spectral Imaging, (2 July 2001); doi: 10.1117/12.432493
Show Author Affiliations
Yuko Fukami, Osaka Univ. (Japan)
Manabu Heya, Osaka Univ. (Japan)
Kunio Awazu, Osaka Univ. (Japan)

Published in SPIE Proceedings Vol. 4259:
Biomarkers and Biological Spectral Imaging
Gregory H. Bearman; Darryl J. Bornhop; Richard M. Levenson; Darryl J. Bornhop, Editor(s)

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