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Proceedings Paper

Photodynamic therapy for bladder carcinoma: today's medicine or tomorrow's horizon?
Author(s): J. C. Picard; Werner T.W. de Riese; Brent A. Sharpe
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Paper Abstract

Transitional cell carcinoma (TCC) of the bladder has a 40-70% local recurrence rate when treated with transurethral resection (TURBT)1 and carcinoma in situ (CIS) has a 54-83% recurrence rate within 4 years2. Today, the main therapy is intravesical chemotherapy, of which Bacillus Calmette-Guerin (BCG) is the most effective. However, because chemotherapy is only modestly beneficial3 and most bladder carcinomas will not respond to second course of BCG4, an additional treatment modality is being researched. Photodynamic therapy (PDT) combines a photosensitizing dye with laser therapy to destroy cancer cells. Pathologic cells take up the photosensitizing agent and upon activation by visible light (400 - 760 nm) the cancerous cells are destroyed. PDT can be used for focal or diffuse disease. It also can be used to treat recurrent and refractory superficial TCC, in addition to being used as a prophylactic measure. We review the literature (mostly retrospective or nonrandomized studies) that supports the use of PDT for TCC of the bladder. While PDT seems to be a very promising treatment modality, BGC intravesical treatment remains the standard of care for TCC. However if additional randomized trials confirm current data, PDT may soon be a recommendable option.

Paper Details

Date Published: 17 June 2002
PDF: 8 pages
Proc. SPIE 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII, (17 June 2002); doi: 10.1117/12.432128
Show Author Affiliations
Brent A. Sharpe

Published in SPIE Proceedings Vol. 4609:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII
Lawrence S. Bass; Eugene A. Trowers; Kenneth Eugene Bartels; Udayan K. Shah; David S. Robinson; Lawrence S. Bass; Kenton W. Gregory; Kenneth Eugene Bartels; Lawrence S. Bass; Brian Jet-Fei Wong; Hans-Dieter Reidenbach; Lloyd P. Tate; Nikiforos Kollias; Abraham Katzir; Timothy A. Woodward; Werner T.W. de Riese; George M. Peavy; Werner T.W. de Riese; Kenton W. Gregory; Michael D. Lucroy; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy; Reza S. Malek; George M. Peavy; Hans-Dieter Reidenbach; David S. Robinson; Udayan K. Shah; Lloyd P. Tate; Eugene A. Trowers; Brian Jet-Fei Wong; Timothy A. Woodward, Editor(s)

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