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Proceedings Paper

Minimally invasive treatment of benign prostatic hyperplasia with high-intensity focused ultrasound using the Sonablate system: an updated report of Phase III clinical studies conducted in the USA
Author(s): Thomas A. Gardner; Michael O. Koch; Arieh Shalhav; Richard Bihrle; Richard S. Foster; Christopher Steidle; Ivan Grunberger; Alan Seftel; Martin Resnick; James Cochran; Victor Rao; Narendra T. Sanghvi
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Paper Abstract

Phase III multicenter study was conducted in the USA under the FDA approved protocol, to establish the safety and efficacy of High Intensity Focused Ultrasound (HIFU) in the treatment of Benign Prostatic Hyperplasia (BPH) using the Sonablate? system. A total of sixty eight patients have been treated to date in the Phase III study. Transrectal probes capable of real-time ultrasound imaging of the prostate and well as delivering the HIFU energy to the selected region in the prostate gland were used. Probes with different focal lengths were used to treat different size of prostate glands. The patients were treated in one treatment session and were followed up to a period of one year following the treatment. The subjects underwent physical exam, Digital Rectal Examination (DRE), cystoscopy, Transrectal Ultrasound (TRUS), blood work, urine exam and were given standard questionnaires before treatment and during the follow up period. Under this protocol HIFU was found to be safe and effective in reducing the BPH related symptoms and improving the peak urinary flow rate with preservation of sexual function and no permanent side effects.

Paper Details

Date Published: 17 June 2002
PDF: 8 pages
Proc. SPIE 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII, (17 June 2002); doi: 10.1117/12.432046
Show Author Affiliations
Thomas A. Gardner
Michael O. Koch
Arieh Shalhav
Richard Bihrle
Richard S. Foster
Christopher Steidle
Ivan Grunberger
Alan Seftel
Martin Resnick
James Cochran
Victor Rao
Narendra T. Sanghvi

Published in SPIE Proceedings Vol. 4609:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII
Lawrence S. Bass; Eugene A. Trowers; Kenneth Eugene Bartels; Udayan K. Shah; David S. Robinson; Lawrence S. Bass; Kenton W. Gregory; Kenneth Eugene Bartels; Lawrence S. Bass; Brian Jet-Fei Wong; Hans-Dieter Reidenbach; Lloyd P. Tate; Nikiforos Kollias; Abraham Katzir; Timothy A. Woodward; Werner T.W. de Riese; George M. Peavy; Werner T.W. de Riese; Kenton W. Gregory; Michael D. Lucroy; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy; Reza S. Malek; George M. Peavy; Hans-Dieter Reidenbach; David S. Robinson; Udayan K. Shah; Lloyd P. Tate; Eugene A. Trowers; Brian Jet-Fei Wong; Timothy A. Woodward, Editor(s)

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