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Proceedings Paper

Sedimentation of immersed blood studied by OCT
Author(s): Valery V. Tuchin; Xiangqun Xu; Ruikang K. Wang
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Paper Abstract

The concept of refractive index matching used for the enhancement of optical penetration depth of the whole blood is discussed on the basis of in vitro studies. It was stated that blood optical clearing is defined not only by refractive index matching effect, but also by changes of RBC size and their aggregation ability when chemicals are added. For example, for whole blood twice diluted by a saline adding of 6.5% of glycerol reduces the total attenuation coefficient from 4.2 mm-1 to 2.0 mm-1, and correspondingly increases substantially the optical penetration up to 117%. For other tested agents (three types of dextrans A, B, and C; propylene glycol; and trazograph, all at concentration 6.5%) the enhancement of penetration was from 20.5% (for low molecular dextran) up to 77.2% for propylene glycol. For non-diluted blood such effects were not very pronounced, but still glycerol at 13% has the highest enhancement up to 52% and the total attenuation coefficient was changed from 6.1 to 5.1 mm-1.

Paper Details

Date Published: 4 May 2001
PDF: 13 pages
Proc. SPIE 4241, Saratov Fall Meeting 2000: Optical Technologies in Biophysics and Medicine II, (4 May 2001); doi: 10.1117/12.431547
Show Author Affiliations
Valery V. Tuchin, Saratov State Univ. (Russia)
Xiangqun Xu, Keele Univ. (United Kingdom)
Ruikang K. Wang, Keele Univ. School of Medicine (United Kingdom)

Published in SPIE Proceedings Vol. 4241:
Saratov Fall Meeting 2000: Optical Technologies in Biophysics and Medicine II
Valery V. Tuchin, Editor(s)

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