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Proceedings Paper

Feasibility of using diffuse reflectance spectroscopy for the quantification of brain edema
Author(s): Juan G. Rodriguez; Cynthia Sisson; Chad Hendricks; Chris Pattillo; Megan McWaters; Mardjohan Hardjasudarma; Chad Quarles; Anna N. Yaroslavsky; Ilya V. Yaroslavsky; Harold Battarbee
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Paper Abstract

Many diseased states of the brain can result in the displacement of brain tissues and restrict cerebral blood flow, disrupting function in a life-threatening manner. Clinical examples where displacements are observed include venous thromboses, hematomas, strokes, tumors, abscesses, and, particularly, brain edema. For the latter, the brain tissue swells, displacing the cerebral spinal fluid (CSF) layer that surrounds it, eventually pressing itself against the skull. Under such conditions, catheters are often inserted into the brain's ventricles or the subarachnoid space to monitor increased pressure. These are invasive procedures that incur increased risk of infection and consequently are used reluctantly by clinicians. Recent studies in the field of biomedical optics have suggested that the presence or absence of the CSF layer can lead to dramatic changes in NIR signals obtained from diffuse reflectance measurements around the head. In this study, we consider how this sensitivity of NIR signals to CSF might be exploited to non-invasively monitor the onset and resolution of brain edema.

Paper Details

Date Published: 4 May 2001
PDF: 10 pages
Proc. SPIE 4241, Saratov Fall Meeting 2000: Optical Technologies in Biophysics and Medicine II, (4 May 2001); doi: 10.1117/12.431509
Show Author Affiliations
Juan G. Rodriguez, Centenary College of Louisiana and Louisiana State Univ. Health Sciences Ctr. (United States)
Cynthia Sisson, Louisiana State Univ. (United States)
Chad Hendricks, Centenary College of Louisiana (United States)
Chris Pattillo, Centenary College of Louisiana (United States)
Megan McWaters, Centenary College of Louisiana (United States)
Mardjohan Hardjasudarma, Louisiana State Univ. Health Sciences Ctr. (United States)
Chad Quarles, Medical College of Wisconsin (United States)
Anna N. Yaroslavsky, Louisiana State Univ. Health Sciences Ctr. (United States)
Ilya V. Yaroslavsky, Louisiana State Univ. Health Sciences Ctr. (United States)
Harold Battarbee, Louisiana State Univ. Health Sciences Ctr. (United States)


Published in SPIE Proceedings Vol. 4241:
Saratov Fall Meeting 2000: Optical Technologies in Biophysics and Medicine II
Valery V. Tuchin, Editor(s)

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