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Proceedings Paper

Correction of geometric distortions in EP images using nonrigid registration to corresponding anatomic images
Author(s): Darko Skerl; Shiyan Pan; Rui Li; J. Michael Fitzpatrick; Mitchell H. Parks; Peter R. Martin; Victoria L. Morgan; Benoit M. Dawant
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Paper Abstract

The spatial resolution of echo planar image (EPI) data acquired for functional MRI (fMRI) studies is low. To facilitate their interpretation, conventional T1-weighted anatomical images are often acquired prior to the acquisition of the EP images. T1-weighted and EP images are then registered and activation patterns computed from the EP images are superimposed on the anatomic images. Registration between the anatomic and the EP images is required to compensate for patient motion between the acquisitions and for geometric distortions affecting EP images. Recently, methods have been proposed to register EP and anatomic images using non-rigid registration techniques. In these approaches, the transformation is parameterized using splines. Here, we propose an alternative solution to this problem based on optical flow with non-stationary stiffness constraint. The approach we propose also includes several preprocessing steps such as automatic skull removal and intensity remapping. Results obtained with eight studies on normal volunteers are presented.

Paper Details

Date Published: 3 July 2001
PDF: 11 pages
Proc. SPIE 4322, Medical Imaging 2001: Image Processing, (3 July 2001); doi: 10.1117/12.431140
Show Author Affiliations
Darko Skerl, Univ. of Ljubljana (Slovenia)
Shiyan Pan, Vanderbilt Univ. (United States)
Rui Li, Vanderbilt Univ. (United States)
J. Michael Fitzpatrick, Vanderbilt Univ. (United States)
Mitchell H. Parks, Vanderbilt Univ. (United States)
Peter R. Martin, Vanderbilt Univ. (United States)
Victoria L. Morgan, Vanderbilt Univ. (United States)
Benoit M. Dawant, Vanderbilt Univ. (United States)


Published in SPIE Proceedings Vol. 4322:
Medical Imaging 2001: Image Processing
Milan Sonka; Kenneth M. Hanson, Editor(s)

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