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Proceedings Paper

Nonrigid multimodality image registration
Author(s): David Mattes; David R. Haynor; Hubert Vesselle; Thomas K. Lewellyn; William Eubank
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Paper Abstract

We have designed, implemented, and validated an algorithm capable of 3D PET-CT registration in the chest, using mutual information as a similarity criterion. Inherent differences in the imaging protocols produce significant non-linear motion between the two acquisitions. To recover this motion, local deformations modeled with cubic B-splines are incorporated into the transformation. The deformation is defined on a regular grid and is parameterized by potentially several thousand coefficients. Together with a spline-based continuous representation of images and Parzen histogram estimates, the deformation model allows for closed-form expressions of the criterion and its gradient. A limited-memory quasi-Newton optimization package is used in a hierarchical multiresolution framework to automatically align the images. To characterize the performance of the algorithm, 27 scans from patients involved in routine lung cancer screening were used in a validation study. The registrations were assessed visually by two observers in specific anatomic locations using a split window validation technique. The visually reported errors are in the 0-6mm range and the average computation time is 100 minutes.

Paper Details

Date Published: 3 July 2001
PDF: 12 pages
Proc. SPIE 4322, Medical Imaging 2001: Image Processing, (3 July 2001); doi: 10.1117/12.431046
Show Author Affiliations
David Mattes, Univ. of Washington and Univ. of Washington Medical Ctr. (United States)
David R. Haynor, Univ. of Washington and Univ. of Washington Medical Ctr. (United States)
Hubert Vesselle, Univ. of Washington and Univ. of Washington Medical Ctr. (United States)
Thomas K. Lewellyn, Univ. of Washington and Univ. of Washington Medical Ctr. (United States)
William Eubank, Univ. of Washington and Univ. of Washington Medical Ctr. (United States)


Published in SPIE Proceedings Vol. 4322:
Medical Imaging 2001: Image Processing
Milan Sonka; Kenneth M. Hanson, Editor(s)

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