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Proceedings Paper

Objective and reproducible segmentation and quantification of tuberous sclerosis lesions in FLAIR brain MR images
Author(s): Tanja Alderliesten; Wiro J. Niessen; Koen L. Vincken; J. B. Antoine Maintz; Floor Jansen; Onno van Nieuwenhuizen; Max A. Viergever
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Paper Abstract

A semi-automatic segmentation method for Tuberous Sclerosis (TS) lesions in the brain has been developed. Both T1 images and Fluid Attenuated Inversion Recovery (FLAIR) images are integrated in the segmentation procedure. The segmentation procedure is mainly based on the notion of fuzzy connectedness. This approach uses the two basic concepts of adjacency and affinity to form a fuzzy relation between voxels in the image. The affinity is defined using two quantities that are both based on characteristics of the intensities in the lesion and surrounding brain tissue (grey and white matter). The semi-automatic method has been compared to results of manual segmentation. Manual segmentation is prone to interobserver and intraobserver variability. This was especially true for this particular study, where large variations were observed, which implies that a golden standard for comparison was not available. The method did perform within the variability of the observers and therefore has the potential to improve reproducibility of quantitative measurements.

Paper Details

Date Published: 3 July 2001
PDF: 10 pages
Proc. SPIE 4322, Medical Imaging 2001: Image Processing, (3 July 2001); doi: 10.1117/12.431033
Show Author Affiliations
Tanja Alderliesten, Univ. Medical Ctr. Utrecht (Netherlands)
Wiro J. Niessen, Univ. Medical Ctr. Utrecht (Netherlands)
Koen L. Vincken, Univ. Medical Ctr. Utrecht (Netherlands)
J. B. Antoine Maintz, Utrecht Univ. (Netherlands)
Floor Jansen, Univ. Medical Ctr. Utrecht (Netherlands)
Onno van Nieuwenhuizen, Univ. Medical Ctr. Utrecht (Netherlands)
Max A. Viergever, Univ. Medical Ctr. Utrecht (Netherlands)

Published in SPIE Proceedings Vol. 4322:
Medical Imaging 2001: Image Processing
Milan Sonka; Kenneth M. Hanson, Editor(s)

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