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Proceedings Paper

Simultaneous assessment of human brain functional hemodynamics by magnetic resonance and near-infrared imaging
Author(s): Vladislav Yu. Toronov; Andrew Webb; Jee Hyun Choi; Martin Wolf; Enrico Gratton
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Paper Abstract

Near-infrared spectroscopy is a relatively new imaging method, which can provide important information on concentrations of oxy-and deoxy-hemoglobin in cortical areas of the brain. We discuss the advantages of the integration of magnetic resonance and optical imaging techniques and present the results of our experimental study on the comparison of optical and fMRI signals obtained simultaneously on humans during functional activity and at rest. In all subjects we found a good collocation of the brain activity centers revealed by both methods. We also found a high temporal correlation between the BOLD signal (fMRI) and the deoxy-hemoglobin concentration (near-infrared spectroscopy) in the subjects who exhibited low fluctuations in superficial head tissues. The contamination of optical signals by superficial tissue layers urges applying algorithms of three-dimensional optical tomography.

Paper Details

Date Published: 28 June 2001
PDF: 7 pages
Proc. SPIE 4320, Medical Imaging 2001: Physics of Medical Imaging, (28 June 2001); doi: 10.1117/12.430911
Show Author Affiliations
Vladislav Yu. Toronov, Univ. of Illinois/Urbana-Champaign (United States)
Andrew Webb, Univ. of Illinois/Urbana-Champaign (United States)
Jee Hyun Choi, Univ. of Illinois/Urbana-Champaign (United States)
Martin Wolf, Univ. of Illinois/Urbana-Champaign (United States)
Enrico Gratton, Univ. of Illinois/Urbana-Champaign (United States)

Published in SPIE Proceedings Vol. 4320:
Medical Imaging 2001: Physics of Medical Imaging
Larry E. Antonuk; Martin Joel Yaffe, Editor(s)

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