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Proceedings Paper

Tailoring the x-ray beam energy spectrum to enhance image quality of new radiography contrast agents based on Gd or other lanthanides
Author(s): F. Avraham Dilmanian; Hanns-Joachim Weinmann; Zhong Zhong; Tigran Bacarian; Luigi Rigon; Terry M. Button; Baorui Ren; Xiaoye Wu; Nan Zhong; Harold L. Atkins
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Paper Abstract

Gadovist, a 1.0-molar Gd contrast agent from Schering AG, Berlin, Germany, in use in clinical MRI in Europe, was evaluated as a radiography contrast agent. In a collaboration with Brookhaven National Laboratory (BNL), Schering AG is developing several such lanthanide-based contrast agents, while BNL evaluates them using different x-ray beam energy spectra. These energy spectra include a 'truly' monochromatic beam (0.2 keV energy bandwidth) from the National Synchrotron Light Source (NSLS), BNL, tuned above the Gd K-edge, and x-ray-tube beams from different kVp settings and beam filtrations. Radiographs of rabbits' kidneys were obtained with Gadovist at the NSLS. Furthermore, a clinical radiography system was used for imaging rabbits' kidneys comparing Gadovist and Conray, an iodinated contrast agent. The study, using 74 kVp and standard Al beam filter for Conray and 66 kVp and an additional 1.5 mm Cu beam filter for Gadovist, produced comparable images for Gadovist and Conray; the injection volumes were the same, while the radiation absorbed dose for Gadovist was slightly smaller. A bent-crystal silicon monochromator operating in the Laue diffraction mode was developed and tested with a conventional x-ray tube beam; it narrows the energy spectrum to about 4 keV around the anode tungsten's K' line. Preliminary beam-flux results indicate that the method could be implemented in clinical CT if x-ray tubes with approximately twice higher output become available.

Paper Details

Date Published: 28 June 2001
PDF: 10 pages
Proc. SPIE 4320, Medical Imaging 2001: Physics of Medical Imaging, (28 June 2001); doi: 10.1117/12.430904
Show Author Affiliations
F. Avraham Dilmanian, Brookhaven National Lab. (United States)
Hanns-Joachim Weinmann, Schering AG (Germany)
Zhong Zhong, Brookhaven National Lab. (United States)
Tigran Bacarian, Brookhaven National Lab. (United States)
Luigi Rigon, Univ. of Trieste (Italy)
Terry M. Button, SUNY/Stony Brook (United States)
Baorui Ren, Brookhaven National Lab. (United States)
Xiaoye Wu, Brookhaven National Lab. (United States)
Nan Zhong, Brookhaven National Lab. (United States)
Harold L. Atkins, Brookhaven National Lab. (United States)

Published in SPIE Proceedings Vol. 4320:
Medical Imaging 2001: Physics of Medical Imaging
Larry E. Antonuk; Martin Joel Yaffe, Editor(s)

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