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Proceedings Paper

Tissue soldering with biodegradable polymer films: preliminary in-vivo compatibility test
Author(s): Brian S. Sorg; Ashley J. Welch
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Paper Abstract

Previous in vitro laser-tissue welding research demonstrated a technique to improve the acute breaking strength of liquid albumin solder using biodegradable polymer film reinforcement. This study’s purpose was to explore what problems could arise in vivo that were not evident in vitro. Full thickness incisions were created on the dorsum of Sprague-Dawley rats. A poly(lactic-co-glycolic acid) (PLGA) film was subcutaneously implanted in the incision (controls had no film). The incisions were closed by laser-tissue welding: albumin solder with Indocyanine Green dye was inserted between the incision edges and coagulated with a diode laser. Specimens were harvested at 0, 3, 7, and 14 days for strength testing and histologic analysis. Histology indicated that the PLGA film was relatively well tolerated by the tissue. Breaking strengths of controls at 0 and 14 days were stronger than specimens with implanted films (t-test, P < 0.05). Difficulty apposing the incision edges due to the film presence probably contributed to low acute strengths. Interference with wound contraction by the films possibly contributed to lower breaking strengths at 14 days. Polymer films for patch reinforcement of solder may be clinically feasible; however, application specific problems can occur and should be considered when developing a clinical technique.

Paper Details

Date Published: 17 June 2002
PDF: 10 pages
Proc. SPIE 4609, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII, (17 June 2002); doi: 10.1117/12.430664
Show Author Affiliations
Ashley J. Welch

Published in SPIE Proceedings Vol. 4609:
Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XII
Lawrence S. Bass; Abraham Katzir; Eugene A. Trowers; Timothy A. Woodward; Werner T.W. de Riese; Kenneth Eugene Bartels; Lloyd P. Tate; George M. Peavy; Michael D. Lucroy; Lawrence S. Bass; Nikiforos Kollias; Kenton W. Gregory; Udayan K. Shah; Brian Jet-Fei Wong; David S. Robinson; Hans-Dieter Reidenbach; Kenneth Eugene Bartels; Lawrence S. Bass; Werner T.W. de Riese; Kenton W. Gregory; Abraham Katzir; Nikiforos Kollias; Michael D. Lucroy; Reza S. Malek; George M. Peavy; Hans-Dieter Reidenbach; David S. Robinson; Udayan K. Shah; Lloyd P. Tate; Eugene A. Trowers; Brian Jet-Fei Wong; Timothy A. Woodward, Editor(s)

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