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Proceedings Paper

Development of an implantable skin port sensor for use as an in-vivo optical glucose sensing platform
Author(s): Ashok Gowda; Roger J. McNichols; Theresa W. Fossum; Sohi Rastegar; Gerard L. Cote
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Paper Abstract

Factors that have limited the acceptance of optical spectroscopy methods for non-invasive blood glucose sensing include signal variations due in part to changes in the skin tissue optics between patients, the lack of a repeatable pathlength inherent in using diffusely reflected photon approaches, temperature variations on the skin, and the pressure with which a probe is applied to the skin surface. Unfortunately, most previous approaches to non-invasive glucose sensing have failed to address these important issues. In this work, we developed a novel skin port sensor (SPS) which eliminates the effect of skin optics by using a stable, infection-free, dermal implant to provide a skinless window into the body. Our implant is designed to provide a fixed optical pathlength as well as features to minimize temperature and pressure variations. Preliminary experiments in a pig model demonstrate both a stable biological seal at the transcutaneous interface as well as ingrowth of vascular containing granulation tissue within the sensing chamber. Furthermore, optical spectra acquired from the port demonstrate changes in glucose signatures related to concentration changes induced in the blood. Our novel SPS may provide the necessary platform for successful implementation of an optical approach to in vivo glucose sensing.

Paper Details

Date Published: 13 June 2001
PDF: 9 pages
Proc. SPIE 4263, Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring, (13 June 2001); doi: 10.1117/12.429333
Show Author Affiliations
Ashok Gowda, BioTex, Inc. (United States)
Roger J. McNichols, BioTex, Inc. (United States)
Theresa W. Fossum, Texas A&M Univ. (United States)
Sohi Rastegar, Texas A&M Univ. (United States)
Gerard L. Cote, Texas A&M Univ. (United States)

Published in SPIE Proceedings Vol. 4263:
Optical Diagnostics and Sensing of Biological Fluids and Glucose and Cholesterol Monitoring
Alexander V. Priezzhev; Gerard L. Cote, Editor(s)

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