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Proceedings Paper

Maximum tolerable dose (MTD): a new index for ultraviolet radiation toxicity in the lens
Author(s): Per G. Soderberg; Stefan Lofgren; Marcelo Ayala; M. Kakar
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Paper Abstract

The maximum tolerable dose (MTD2.3:16) for avoidance of cataract on exposure to UVR-300 nm in the rat was currently estimated to 3.65 kJ/m2. For this, Sprague-Dawley rats were unilaterally exposed to UVR in the 300 nm wavelength region, generated with a high pressure mercury arc source. The intensity of forward light scattering was measured one week after exposure. MTD allows estimation of toxicity for continuous response events with small sample experiments. Current safety standards for avoidance of cataract after exposure to UVR are based on a binary response event. It has however recently been shown that UVR-induced cataract is a continuous dose-dependent event. MTD provides a statistically well defined criterium of toxicity for continuous response events.

Paper Details

Date Published: 7 June 2001
PDF: 4 pages
Proc. SPIE 4245, Ophthalmic Technologies XI, (7 June 2001); doi: 10.1117/12.429275
Show Author Affiliations
Per G. Soderberg, St. Erik's Eye Hospital/Karolinska Institute and Univ. of Miami (Sweden)
Stefan Lofgren, St. Erik's Eye Hospital/Karolinska Institute (Sweden)
Marcelo Ayala, St. Erik's Eye Hospital/Karolinska Institute (Sweden)
M. Kakar, St. Erik's Eye Hospital/Karolinska Institute (Sweden)


Published in SPIE Proceedings Vol. 4245:
Ophthalmic Technologies XI
Fabrice Manns; Per G. Soederberg; Arthur Ho, Editor(s)

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