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Proceedings Paper

Raman detection of carotenoid pigments in the human retina
Author(s): Werner Gellermann; Igor V. Ermakov; Maia R. Ermakova; Robert W. McClane; Steven W. Wintch; Da-You Zhao; Paul S. Bernstein
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Paper Abstract

We have used resonant Raman scattering as a novel, non- invasive, in-vivo optical technique to measure the concentration of macular carotenoid pigments in the living human retina of young and elderly adults. Using a backscattering geometry and resonant molecular excitation in the visible, we measure the Raman peaks originating from the single- and double-bond stretch vibrations of the (pi) - electron conjugated molecule's carbon backbone. The Raman signals scale linearly with carotenoid content while the required laser excitation is well below safety limits for macular exposure. Measured macular pigment levels decline significantly with increasing age. The Raman technique is objective and quantitative and may lead to a new method for rapid screening of carotenoid pigment levels in large populations at risk for vision loss from age-related macular degeneration, the leading cause of blindness in the elderly in the United States.

Paper Details

Date Published: 7 June 2001
PDF: 12 pages
Proc. SPIE 4245, Ophthalmic Technologies XI, (7 June 2001); doi: 10.1117/12.429266
Show Author Affiliations
Werner Gellermann, Univ. of Utah (United States)
Igor V. Ermakov, Univ. of Utah (United States)
Maia R. Ermakova, Univ. of Utah (United States)
Robert W. McClane, Univ. of Utah (United States)
Steven W. Wintch, Univ. of Utah (United States)
Da-You Zhao, Univ. of Utah School of Medicine (United States)
Paul S. Bernstein, Univ. of Utah School of Medicine (United States)


Published in SPIE Proceedings Vol. 4245:
Ophthalmic Technologies XI
Fabrice Manns; Per G. Soederberg; Arthur Ho, Editor(s)

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