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Proceedings Paper

Brain miner: a 3D visual interface for the investigation of functional relationships in the brain
Author(s): Tom F. Welsh; Klaus D. Mueller; Wei Zhu; Jeffrey R. Meade; Nora Volkow
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Paper Abstract

Brain imaging methods used in experimental brain research such as Positron Emission Tomography (PET) and Functional Magnetic Resonance (fMRI) require the analysis of large amounts of data. Statistical methods are necessary to obtain a reliable measure of a given effect. Typically, researchers report their findings by listing those regions which show significant statistical activity in a group of subjects under some experimental condition or task. A number of methods create statistical parametric maps (SPMs) of the brain on a voxel- basis. However, a major limitation of the voxel-based technique is the inaccuracy of the transformation into a stereotaxic space (e.g., Talairach-Tournoux) given the wide variability in human brain structure. In order to account for this, researchers have turned to computing the statistics not on individual voxels but on predefined anatomical regions-of- interest (ROIs). A correlation coefficient is used to quantify similarity in response for various regions during an experimental setting. Since the functional inter-relationships can become rather complex, they are best understood in the context of the underlying 3-D brain anatomy. In this paper, we present a novel 3-D interface that allows the interactive exploration of the correlation datasets within a common stereotaxic atlas.

Paper Details

Date Published: 21 May 2001
PDF: 5 pages
Proc. SPIE 4321, Medical Imaging 2001: Physiology and Function from Multidimensional Images, (21 May 2001); doi: 10.1117/12.428163
Show Author Affiliations
Tom F. Welsh, SUNY/Stony Brook (United States)
Klaus D. Mueller, SUNY/Stony Brook (United States)
Wei Zhu, SUNY/Stony Brook (United States)
Jeffrey R. Meade, SUNY/Stony Brook (United States)
Nora Volkow, Brookhaven National Lab. (United States)

Published in SPIE Proceedings Vol. 4321:
Medical Imaging 2001: Physiology and Function from Multidimensional Images
Chin-Tu Chen; Anne V. Clough, Editor(s)

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