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Proceedings Paper

New method for quantitative analysis of multiple scelerosis using MR images
Author(s): Dongqing Chen; Wei Huang; C. Christodoulou; Lihong Li; Huayuan Qian; Lauren Krupp; Zhengrong Liang
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Paper Abstract

A method for quantitative analysis of multiple sclerosis (MS) was presented. An automatic self-adaptive image segmentation algorithm was first employed to classify voxels in multi- spectral magnetic resonance (MR) images. The segmentation results from multi-spectral MR images were then combined to obtain reliable results. The volumes of brain tissues and cerebral spinal fluid (CSF) were finally extracted. Since it is fully automated, the results of the segmentation algorithm are completely reproducible. The repeatability of the presented method was evaluated on volunteer data sets. The variation is less than 0.2% for the intra-cranial volume, the whole brain volume, the central CSF, the white matter (WM) and the gray matter (GM). The variation of 3% for the entire CSF is mainly due to the peripheral CSF part, which has more partial volume effect and is less important than the central one. Methods for minimizing this variation are under investigation. These measurements demonstrate the potential for study on whole brain atrophy and cerebral atrophy. Feasibility studies on 14 MS patients were performed. The results are promising.

Paper Details

Date Published: 21 May 2001
PDF: 6 pages
Proc. SPIE 4321, Medical Imaging 2001: Physiology and Function from Multidimensional Images, (21 May 2001); doi: 10.1117/12.428160
Show Author Affiliations
Dongqing Chen, SUNY/Stony Brook (United States)
Wei Huang, SUNY/Stony Brook (United States)
C. Christodoulou, SUNY/Stony Brook (United States)
Lihong Li, SUNY/Stony Brook (United States)
Huayuan Qian, SUNY/Stony Brook (United States)
Lauren Krupp, SUNY/Stony Brook (United States)
Zhengrong Liang, SUNY/Stony Brook (United States)

Published in SPIE Proceedings Vol. 4321:
Medical Imaging 2001: Physiology and Function from Multidimensional Images
Chin-Tu Chen; Anne V. Clough, Editor(s)

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