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Proceedings Paper

Multimodality localization of epileptic foci
Author(s): Manuel Desco; Javier Pascau; M A Pozo; Andres Santos; Santiago Reig; Juan D. Gispert; Pedro Garcia-Barreno
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Paper Abstract

This paper presents a multimodality approach for the localization of epileptic foci using PET, MRI and EEG combined without the need of external markers. Mutual Information algorithm is used for MRI-PET registration. Dipole coordinates (provided by BESA software) are projected onto the MRI using a specifically developed algorithm. The four anatomical references used for electrode positioning (nasion, inion and two preauricular points) are located on the MRI using a triplanar viewer combined with a surface-rendering tool. Geometric transformation using deformation of the ideal sphere used for dipole calculations is then applied to match the patient's brain size and shape. Eight treatment-refractory epileptic patients have been studied. The combination of the anatomical information from the MRI, hipoperfusion areas in PET and dipole position and orientation helped the physician in the diagnosis of epileptic focus location. Neurosurgery was not indicated for patients where PET and dipole results were inconsistent; in two cases it was clinically indicated despite the mismatch, showing a negative follow up. The multimodality approach presented does not require external markers for dipole projection onto the MRI, this being the main difference with previous methods. The proposed method may play an important role in the indication of surgery for treatment- refractory epileptic patients.

Paper Details

Date Published: 21 May 2001
PDF: 9 pages
Proc. SPIE 4321, Medical Imaging 2001: Physiology and Function from Multidimensional Images, (21 May 2001); doi: 10.1117/12.428158
Show Author Affiliations
Manuel Desco, Hospital Univ. G. Maranon (Spain)
Javier Pascau, Hospital Univ. G. Maranon (Spain)
M A Pozo, Univ. Complutense de Madrid (Spain)
Andres Santos, Univ. Politecnica de Madrid (Spain)
Santiago Reig, Hospital Univ. G. Maranon (Spain)
Juan D. Gispert, Hospital Univ. G. Maranon (Spain)
Pedro Garcia-Barreno, Hospital Univ. G. Maranon (Spain)


Published in SPIE Proceedings Vol. 4321:
Medical Imaging 2001: Physiology and Function from Multidimensional Images
Chin-Tu Chen; Anne V. Clough, Editor(s)

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