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Proceedings Paper

Pulmonary arterial remodeling revealed by microfocal x-ray tomography
Author(s): Kelly L. Karau; Robert C. Molthen; Roger H. Johnson; Anita H. Dhyani; Steven T. Haworth; Christopher A. Dawson
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Paper Abstract

Animal models and micro-CT imaging are useful for understanding the functional consequences of, and identifying the genes involved in, the remodeling of vascular structures that accompanies pulmonary vascular disease. Using a micro-CT scanner to image contrast-enhanced arteries in excised lungs from fawn hooded rats (a strain genetically susceptible to hypoxia induced pulmonary hypertension), we found that portions of the pulmonary arterial tree downstream from a given diameter were morphometrically indistinguishable. This 'self-consistency' property provided a means for summarizing the pulmonary arterial tree architecture and mechanical properties using a parameter vector obtained from measurements of the contiguous set of vessel segments comprising the longest (principal) pathway and its branches over a range of vascular pressures. This parameter vector was used to characterize the pulmonary vascular remodeling that occurred in rats exposed to a hypoxic (11.5% oxygen) environment and provided the input to a hemodynamic model relating structure to function. The major effect of the remodeling was a longitudinally (pulmonary artery to arterioles) uniform decrease in vessel distensibility that resulted in a 90% increase in arterial resistance. Despite the almost uniform change in vessel distensibility, over 50% of the resistance increase was attributable to vessels with unstressed diameters less than 125 microns.

Paper Details

Date Published: 21 May 2001
PDF: 6 pages
Proc. SPIE 4321, Medical Imaging 2001: Physiology and Function from Multidimensional Images, (21 May 2001); doi: 10.1117/12.428147
Show Author Affiliations
Kelly L. Karau, Marquette Univ. and Medical College of Wisconsin (United States)
Robert C. Molthen, Marquette Univ. and Zablocki VAMC (United States)
Roger H. Johnson, Marquette Univ. and Zablocki VAMC (United States)
Anita H. Dhyani, Marquette Univ. (United States)
Steven T. Haworth, Medical College of Wisconsin (United States)
Christopher A. Dawson, Marquette Univ. and Medical College of Wisconsin and Zablocki VAMC (United States)

Published in SPIE Proceedings Vol. 4321:
Medical Imaging 2001: Physiology and Function from Multidimensional Images
Chin-Tu Chen; Anne V. Clough, Editor(s)

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