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Proceedings Paper

Carbon dioxide reactivity of tumor blood flow as measured by dynamic contrast-enhanced computed tomography: a new treatment protocol for laser thermal therapy
Author(s): Thomas G. Purdie; Michael D. Sherar; Aaron Fenster; Ting-Yim Lee
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Paper Abstract

The purpose of the current study is to measure the carbon dioxide reactivity of blood flow in VX2 tumor in the rabbit thigh. The carbon dioxide reactivity of the functional parameters was investigated in eight rabbits by changing the ventilation rate in order to manipulate the arterial carbon dioxide tension (PaCO2). In each experiment, functional maps were generated at four PaCO2 levels: normocapnia (PaCO2 equals 40.7 +/- 1.4 mm Hg), hypocapnia (27.1 +/- 2.5 and 33.7 +/- 2.2) and hypercapnia (53.8 +/- 5.2). The carbon dioxide reactivity of tumor blood flow showed significant differences between normocapnia and the two levels of hypocapnia, but not between normocapnia and hypercapnia. The average fractional change of blood flow from normocapnia for the two hypocapnic level was -0.41 +/- 0.06 and -0.29 +/- 0.08, respectively. The ability to reduce blood flow through hypocapnia has significant implications in thermal therapy, as heat dissipation represents a major obstacle which limits the effectiveness of treatment.

Paper Details

Date Published: 21 May 2001
PDF: 11 pages
Proc. SPIE 4321, Medical Imaging 2001: Physiology and Function from Multidimensional Images, (21 May 2001); doi: 10.1117/12.428122
Show Author Affiliations
Thomas G. Purdie, John P. Robarts Research Institute/Univ. of Western Ontario (Canada)
Michael D. Sherar, Ontario Cancer Institute and Univ. of Toronto (Canada)
Aaron Fenster, John P. Robarts Research Institute/Univ. of Western Ontario (Canada)
Ting-Yim Lee, John P. Robarts Research Institute/Univ. of Western Ontario (Canada)


Published in SPIE Proceedings Vol. 4321:
Medical Imaging 2001: Physiology and Function from Multidimensional Images
Chin-Tu Chen; Anne V. Clough, Editor(s)

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