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Proceedings Paper

Three-dimensional correlation of MR images to muscle tissue response for interventional MRI thermal ablation
Author(s): Michael S. Breen; Tanya L. Lancaster; Roee S. Lazebnik; Andrik J. Ashcroft; Sherif Gamal Nour; Jonathan S. Lewin; David L. Wilson
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Paper Abstract

We are treating tumors using radiofrequency (RF) ablation under interventional MRI (iMRI) guidance. We investigated the ability of MR to monitor the treated region by comparing MR thermal lesion images to cellular damage as seen histologically. Our new methodology allows 3D registration that should enable more accurate correlation than previous 2D methods. Using a low-field (0.2T) open magnet iMRI system for probe guidance, we applied RF ablation to the thigh muscle of four New Zealand White rabbits. To relate in vivo MR and histology images, we obtained intermediate ex vivo MR images and pictures of thick tissue slices obtained using a specially designed apparatus. Registration was done with a computer algorithm that matches tracks of needle fiducials placed near the tissue of interest. After registration, we determined the region inside the circular, hyperintense rim in MR closely corresponds to the region of necrosis as determined by histology on animals sacrificed 30 minutes after ablation. This is good evidence that iMRI images can be used for real-time feedback during thermal RF ablation treatments.

Paper Details

Date Published: 28 May 2001
PDF: 10 pages
Proc. SPIE 4319, Medical Imaging 2001: Visualization, Display, and Image-Guided Procedures, (28 May 2001); doi: 10.1117/12.428056
Show Author Affiliations
Michael S. Breen, Case Western Reserve Univ. (United States)
Tanya L. Lancaster, Case Western Reserve Univ. (United States)
Roee S. Lazebnik, Case Western Reserve Univ. (United States)
Andrik J. Ashcroft, Univ. Hospitals of Cleveland and Case Western Reserve Univ. (United States)
Sherif Gamal Nour, Univ. Hospitals of Cleveland, Case Western Reserve Univ., and Cairo Univ. Hospitals (United States)
Jonathan S. Lewin, Univ. Hospitals of Cleveland and Case Western Reserve Univ. (United States)
David L. Wilson, Case Western Reserve Univ., Univ. Hospitals of Cleveland, and Case Western Univ. (United States)

Published in SPIE Proceedings Vol. 4319:
Medical Imaging 2001: Visualization, Display, and Image-Guided Procedures
Seong Ki Mun, Editor(s)

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